Patch a Therm-a-Rest camping mat
I live in the desert. This is a cholla (say CHOY ya) cactus forest. Cholla spines get into everything. I camp a lot and use a Therm-a-Rest self-inflating mattress, which around here is jokingly referred to as a PermaFlat, because of the prickly nature of the environment.
When the mattress doesn't have any holes in it, it's super comfy. Therma-Rest makes a repair kit which is a huge inconvenience to use either in the field or at home. I just repaired my most recent puncture with sugru - MUCH easier than the manufacturers repair kit! I'm so pleased! By sugru guru @janetplanet (bit.ly/OeeLZT)